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Chris Upton, Ph.D. (home page)
Department of Biochemistry and Microbiology
University of Victoria
Victoria, British Columbia
Email: cupton at uvic.ca
I have a long-standing interest in bioinformatics, especially in the identification/prediction of the function of viral genes by database searching. It is clear that standard search techniques are not always adequate to recognize distantly, but significantly related sequences. Examples include the identification of the myxoma interferon-gamma binding protein and the vaccinia uracil DNA glycosylase. More recently we have focused on trying to predict viral genes by examining pI and amino acid content.
We are also developing databases and software to analyze viruses. These tools are useful for the characterization of viral genes, proteins and genomes; they are especially useful for comparative genomic studies and have user-friendly graphical interfaces. A wide variety of virus families are supported.
- Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus
- Cleaning Up Ancient Human DNA for Next Generation Sequencing
- Single-cell RNA-seq transcriptome analysis of linear and circular RNAs | RNA-Seq Blog
- Genomes Tell Story of Native American Biological Origins
- Leaky Vaccines Enhance Spread of Deadlier Chicken Viruses – Phenomena: Not Exactly Rocket Science
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